Wegovy vs Mounjaro
Posted on September 23, 2026 by Sally-Anne Turner
Why Personalised Weight Loss Matters
You’ve heard of Wegovy. You’ve heard of Mounjaro. You’ve read a few articles titled “Wegovy vs Mounjaro” on other pages. Why should this article be different? In simple terms, it explains what we can offer you, how specialised care can affect suitability, and why we believe your care deserves more than a quick prescription sign-off.
When you are looking to lose weight with a GLP-1, it can be daunting. You may be worried that your health history, such as any diagnosed mental health issues, may cause complications. Or, you may have read online about how taking a GLP-1 UK means you must have a spotless medical history.
For many online prescribers, this is the case. However, at Bodyline Clinic, our team will help you find a specialised support plan that accommodates complex medical histories and the GLP-1 medications we offer. Our clinical team is dedicated to making your specialised weight loss journey as easy as possible and, with over 18 years of experience in our weight loss clinic, we can help you choose the right treatment option for your weight loss journey.
You’ve read the articles that compare these two medications at face value. Now, we will dive into why your health history matters, how it may impact side effects, and how our team can support you.
The Medication Basics
Let’s start with a quick rundown of Wegovy vs Mounjaro.
These medications are prescribed in the UK for people who have an NHS BMI of over 27 with weight-related comorbidities, or a BMI of over 30.
As of July 2026, in the UK, you can take Wegovy in two ways. The Wegovy injectable option and the Wegovy pill. Both use semaglutide, but the oral dose is higher because it must be absorbed after passing through stomach acid.
Mounjaro is an injectable GLP-1 medication. Earlier this month, Eli Lilly, the maker of Mounjaro, released an oral GLP-1called Foundayo. We need to highlight here that these are not the same medication. Mounjaro is tirzepatide, and Foundayo is orforglipron.
Side Effects: Do They Differ?
Despite their differing chemical makeup, both Mounjaro and Wegovy are GLP-1s.
However, questions remain about whether the two medications’ side effects differ.
Their shared side effects include:
- Nausea (sometimes called Mounjaro nausea) and vomiting.
- Diarrhoea and constipation.
- Stomach pain and bloating.
As mentioned in our Wegovy Pill UK Side Effects piece, these side effects are more common when you are increasing the dosage, or during what is called dose titration.
Interestingly, when comparing Wegovy vs Mounjaro, there are some differences in other side effects. This may affect your suitability for one over the other, depending on any pre-existing medical conditions.
Switching Medications
We know that when you start a GLP-1, whether it’s oral or injectable, it may not suit you. Even with all the support that you could get from our team!
One thing we can offer as part of our specialised support is help with switching medications. Indeed, there has been a shift since the introduction of the Wegovy pill UK. In simple terms, more people want to have oral options for their weight loss.
If you started on an injectable and want to switch to an oral option, we can help. In this category, coming off Mounjaro and switching to Wegovy is not as simple as simply stopping the injections.
The Medicines and Healthcare Regulatory Agency (MHRA) guidelines state that switching without clinical advice can increase the side effects. It can also make the treatment less effective.
It is advised that, with specialised support, you have:
- You should start the pill on the next scheduled Mounjaro injection day.
- Tirzepatide takes four to five weeks to leave your system. However, a seven-day gap is enough to reduce overlap between the two weight loss treatments and Mounjaro side effects.
You may have started Wegovy and not seen the weight loss you wanted. Research suggests that weight-loss outcomes can differ between GLP-1/GIP treatments. The SURMOUNT-5 trial found that tirzepatide (Mounjaro) produced greater average weight loss than injectable semaglutide (Wegovy) in adults with obesity without type 2 diabetes. As mentioned, when switching from injectables to oral GLP-1 options, the MHRA recommends that a clinical team oversee the switch, which is what we offer at the Bodyline Clinic.
You should never stop taking one medication in the GLP-1 category and start another on your own.
Personalising Your Journey
The issue with clinical research linked to both Mounjaro and Wegovy is that participants often must pass health checks. In simple terms, the real world of taking GLP-1’s rarely reflects the average patient that we see at the Bodyline Clinic.
This can lead to many patients being turned away from GLP-1 treatment that can help them to lose weight. So, what are some of the guidelines linked to Wegovy or Mounjaro related to our areas of specialised care?
Mental Health
For both Mounjaro and Wegovy, NICE Guidelines recommend assessing and managing behavioural support alongside weight-loss treatments. Our team specialise in helping patients who may need behavioural support alongside GLP-1 treatments. So, if you have a mental health issue and want to lose weight, feel free to reach out to talk about Mounjaro antidepressants.
Gastrointestinal Issues
The main similarity between guidelines for both GLP-1s is that if someone has severe gastroparesis, they cannot be prescribed either option. However, milder cases can usually be assessed and have more clinical intervention. You will usually be able to take this medication if you have celiac disease, Crohn’s disease or irritable bowel syndrome (IBS). However, Mounjaro has not been as closely studied for GI issues as Wegovy, so this may affect which medication is chosen to help you lose weight.
Cardiovascular Conditions
Both Wegovy and Mounjaro can impact heart rate and blood pressure. So, if there is an underlying condition, such as hypertension, this can impact treatment. Again, this is not a clear-cut barrier to treatment, but many online pharmacies are not able to offer the monitoring that would be needed for this to be approached safely.
Age over 75
Another issue relating to research is that it rarely encompassed older people in the studies. This leads to many online pharmacies turning people away from weight loss medications that could help them increase their longevity.
The Mounjaro SmPC warns that gastrointestinal side effects such as nausea, vomiting and diarrhoea can lead to dehydration and, in some cases, deterioration in kidney function. It states that this risk should be particularly considered in older people, who may be more susceptible to these complications. Wegovy does not require an age-based dose adjustment, but people in this age group will need monitoring for frailty and often polypharmacy indications.
Why Bodyline is Different with Specialised Weight Loss
At the Bodyline Clinic, we offer more than simply helping our patients to switch from one GLP-1 to another.
We also offer specialised support for weight loss related to any GLP-1 UK if you have:
- A history of cardiovascular issues.
- Gastrointestinal issues.
- A diagnosed mental health issue.
- If you are over the age of 75.
Our team are also set to expand soon into helping people under the age of 18 to lose weight with GLP-1 medications.
Why Choose Bodyline?
As mentioned before, at the Bodyline Clinic, we do more than just sign off on a prescription for Mounjaro vs Wegovy. We take the time to work with your GP or other specialists to assess your health needs, and we will conduct clinical assessments to assess your health. This can also help us to determine the severity of any conditions that you have.
Our team at the Bodyline Clinic have over 18 years of experience helping patients across the UK to lose weight. With 95% 5-star reviews on Trustpilot and over 100,000 people helped, we know what it takes to help patients lose weight safely. Even if pharmacies or GP surgeries have refused you GLP-1 treatment, our team may be able to help you reach your weight-loss goals.
So, if you want to try Mounjaro or Wegovy, or to switch between the two with pre-existing health issues, contact our team today,
FAQs
What are the core Mounjaro Side Effects?
The main side effects of Mounjaro include vomiting, nausea, stomach pain, bloating, diarrhoea, constipation and fatigue. These are also the same side effects that you may experience while taking the Wegovy pill.
What is Mounjaro Nausea?
This occurs when you start taking the Mounjaro injections, or when you increase the dosage of your medication. This can be managed by eating smaller meals, drinking water and avoiding greasy food.
How Do I Choose the Right Weight Loss Injections UK?
There is a lot of information online about choosing weight loss injections near me. However, our team at the Bodyline Clinic think that simply choosing whichever medication has the cheapest prescription is not the best option for everyone. This is especially true if you have a pre-existing health condition. So, if you are stuck or have been rejected by pharmacies for GLP-1s, contact our team today.
