Fibromyalgia is a chronic disorder with widespread symptoms including musculoskeletal pain, fatigue, and tenderness. It is a complex condition and often coexists with other chronic conditions such as migraines, irritable bowel syndrome and depression. Treatment with LDN has provided positive results which have improved quality of life and mental wellbeing of patients. LDN acts on the opioid receptors in the body increasing production and release of endorphins that are natural pain-relieving substances that improve pain management. LDN also reduces inflammation and effects on the central nervous system influencing the transmission of pain signals.